A selective potassium binder

ZS-9 is being investigated for the treatment of hyperkalemia.1

ZS-9 is an insoluble, nonabsorbed zirconium silicate designed to preferentially trap potassium ions in order to lower and maintain control of serum potassium levels. ZS-9 is passed through the digestive tract and eliminated in the stool.1

ZS-9 uses technology that is hypothesized to mimic natural ion channels to make it difficult for ions other than potassium and ammonium to enter its crystalline structure.1




Abbreviations: Si, silicon; Zr, zirconium; O, oxygen; K+, potassium ion; Mg2+, magnesium ion; Ca2+, calcium ion.
For illustrative purposes only. Adapted from Stavros et al, PLoS One, 2014.

Potassium ions pass readily through the ZS-9 pore, while other ions do not.1

  • In an in vitro study, ZS-9 demonstrated a >25-­fold selectivity for potassium over both calcium and magnesium.1

Reference:  1. Stavros F, Yang A, Leon A, Nuttall M, Rasmussen HS. Characterization of structure and function of ZS­-9, a K+ selective ion trap. PLoS One. 2014;9(12):e114686. doi:10.1371/journal.pone.0114686.