ZS Pharma

Committed to Advancing Patient Care


ZS-9 is an insoluble, non-absorbed inorganic crystal that was designed and engineered to preferentially trap potassium ions. We have designed ZS-9 to efficiently bind and remove potassium to treat hyperkalemia without impacting other electrolytes.

In contrast to nonselective polymer resins (sodium polystyrene sulfonate/SPS, or Kayexalate), the current standard of care for hyperkalemia in the U.S., the potassium selectivity of ZS-9 enables high in-vitro binding capacity for potassium ions even in the presence of other ions. Head-to-head in-vitro experiments demonstrate that ZS-9 has roughly ten times the potassium binding capacity of SPS. In our clinical studies, this selectivity has resulted in the following important differentiating characteristics for ZS-9 that we believe support its potential use to treat acute and chronic hyperkalemia:

• high efficacy, with 99% of patients from our completed clinical trials receiving a 10 gram dose;
returning to a normal level of potassium (between 3.5 and 5.0 mEq/L) in their blood within 48 hours;
• rapid onset of action, within hours, shown in our completed clinical trials;
• safely and effectively maintain normal potassium levels in the blood with once-daily administration in studies to date
• easily taken as a convenient oral suspension powder or dissolvable tablets;
• well-tolerated in our studies to date, with an incidence of adverse events similar to placebo;
• no effect on other electrolytes that are critical for normal physiological functioning, including sodium, calcium and magnesium

Recent News

September 17, 2014

ZS Pharma to Present at the 21st Annual BioCentury NewsMakers Conference

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September 15, 2014

ZS Pharma Presents New Data from ZS003 a Two Week Phase 3 Trial Demonstrating that ZS-9 Prevented Recurrence of Hyperkalemia in Heart Failure Patients on RAASi

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September 11, 2014

ZS Pharma to Present Data from Phase 3 Trial of ZS-9 in Late-Breaking Session at Heart Failure Society of America 18th Annual Scientific Meeting

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